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Home - Products - Chromatin/Epigenetic - COX - hCYP3A4 Fluorogenic substrate 1

hCYP3A4 Fluorogenic substrate 1

CAS No. 186299-00-3

hCYP3A4 Fluorogenic substrate 1( —— )

Catalog No. M37062 CAS No. 186299-00-3

hCYP3A4 Fluorogenic substrate 1, a phthalimide derivative, exhibits low activity against COX.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    hCYP3A4 Fluorogenic substrate 1
  • Note
    Research use only, not for human use.
  • Brief Description
    hCYP3A4 Fluorogenic substrate 1, a phthalimide derivative, exhibits low activity against COX.
  • Description
    hCYP3A4 Fluorogenic substrate 1 is a potrnt hCYP3A4 fluorogenic substrate with an Km value of 0.36 μM. hCYP3A4 Fluorogenic substrate 1 can be used for cell and in vivo imaging.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley ratsDosage:10 mg/kg Administration:I.v.Result:Can be used as a probe substrate offers a highly efficient and easy-to-use approach for screening and characterizing hCYP3A4 inhibitors or time-dependent inactivators, which strongly facilitates hCYP3A4-mediated DDI studies.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    186299-00-3
  • Formula Weight
    305.3
  • Molecular Formula
    C19H12FNO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (40.94 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1C=2C=3C(C(=O)N1CC4=CC=C(F)C=C4)=CC=CC3C=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. He RJ, et al. Rationally Engineered CYP3A4 Fluorogenic Substrates for Functional Imaging Analysis and Drug-Drug Interaction Studies. J Med Chem. 2023 May 25;66(10):6743-6755.?
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